A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemicby Alex Salam, Delphine Kayem, Lyndsey Castle and Peter Horby
Determinants of Transmission Risk During the Late Stage of the West African Ebola Epidemicby Conall Watson
A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilotby Louise Sigfrid, Alex Salam and Peter Horby
Ethics preparedness: facilitating ethics review during outbreaks - recommendations from an expert panelby Peter Horby
Comparative Outcomes of Adults Hospitalized With Seasonal Influenza A or B Virus Infection: Application of the 7-Category Ordinal Scale.by Peter Horby
International Biological Reference Preparations for Epidemic Infectious Diseasesby Tommy Rampling, Mark Page, Peter Horby
Clinical research networks and assessing pandemic severityby Srinivas Murthy, Gail Carson, Peter Horby, Laura Merson, Steve Webb
Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infectionby Peter Horby
Performance of different clinical trial designs to evaluate treatments during an epidemicby Matthias Brueckner, Andrew Titman, Thomas Jaki, Amanda Rojek, Peter Horby
In the 2013-2016 west Africa outbreak of Ebola Virus Disease (EVD), most of the planned clinical trials failed to reach a conclusion within the time frame of the epidemic. We conduct a comprehensive evaluation of commonly used two- and multi-arm clinical trial designs based on real data, which was recorded during the 2013-16 EVD epidemic in west Africa
Improving preparedness for the next flu pandemicby Peter Horby
Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutionsby Alex Salam, Amanda Rojek, Jake Dunning, Peter Horby
This article evaluates the major challenges in choosing therapeutics to prevent congenital ZIKV disease and conducting clinical trials of these treatments, with a focus on preventing congenital central nervous system malformations. This article was first published in Annals of Internal Medicine.
GOST: A generic ordinal sequential trial design for a treatment trial in an emerging pandemicby John Whitehead, Peter Horby
This paper proposes a generic ordinal sequential trial design (GOST) for a randomised clinical trial comparing an experimental treatment for an emerging infectious disease with standard care. The design is intended as an off-the-shelf, ready-to-use robust and flexible option. This article was first published in PLOS.