Articles - Tagged as 'Archive'

A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemic

Determinants of Transmission Risk During the Late Stage of the West African Ebola Epidemic

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

Ethics preparedness: facilitating ethics review during outbreaks - recommendations from an expert panel

Comparative Outcomes of Adults Hospitalized With Seasonal Influenza A or B Virus Infection: Application of the 7-Category Ordinal Scale.

International Biological Reference Preparations for Epidemic Infectious Diseases

Clinical research networks and assessing pandemic severity

Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infection

Performance of different clinical trial designs to evaluate treatments during an epidemic

In the 2013-2016 west Africa outbreak of Ebola Virus Disease (EVD), most of the planned clinical trials failed to reach a conclusion within the time frame of the epidemic. We conduct a comprehensive evaluation of commonly used two- and multi-arm clinical trial designs based on real data, which was recorded during the 2013-16 EVD epidemic in west Africa

Improving preparedness for the next flu pandemic

Seminar Recording: Being A Clinical Research Nurse

Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutions

This article evaluates the major challenges in choosing therapeutics to prevent congenital ZIKV disease and conducting clinical trials of these treatments, with a focus on preventing congenital central nervous system malformations. This article was first published in Annals of Internal Medicine.

GOST: A generic ordinal sequential trial design for a treatment trial in an emerging pandemic

This paper proposes a generic ordinal sequential trial design (GOST) for a randomised clinical trial comparing an experimental treatment for an emerging infectious disease with standard care. The design is intended as an off-the-shelf, ready-to-use robust and flexible option. This article was first published in PLOS.