Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease: plasma concentrations exceed target levels, with drug accumulation in the most severe patients

by Janet T. Scott, Raman Sharma, Luke W. Meredith, Jake Dunning, Catrin E. Moore, Foday Sahr, Steve Ward, Ian Goodfellow, Peter Horby, RAPIDE-TKM Trial Team
16th January 2020 • comment

Clinical REsearch During Outbreaks (CREDO) Training for Low- and Middle-Income Countries

by Nzelle Delphine Kayem, Amanda Rojek, Emmanuelle Denis, Alex Salam, Andreas Reis, Piero Olliaro, Peter Horby
2nd December 2019 • comment

A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemic

by Alex Salam, Delphine Kayem, Lyndsey Castle and Peter Horby
25th July 2019 • comment

Determinants of Transmission Risk During the Late Stage of the West African Ebola Epidemic

by Conall Watson
18th July 2019 • comment

Performance of different clinical trial designs to evaluate treatments during an epidemic

by Matthias Brueckner, Andrew Titman, Thomas Jaki, Amanda Rojek, Peter Horby

In the 2013-2016 west Africa outbreak of Ebola Virus Disease (EVD), most of the planned clinical trials failed to reach a conclusion within the time frame of the epidemic. We conduct a comprehensive evaluation of commonly used two- and multi-arm clinical trial designs based on real data, which was recorded during the 2013-16 EVD epidemic in west Africa

17th October 2018 • comment