This paper proposes a generic ordinal sequential trial design (GOST) for a randomised clinical trial comparing an experimental treatment for an emerging infectious disease with standard care. The design is intended as an off-the-shelf, ready-to-use robust and flexible option. This article was first published in PLOS.

24th March 2017 • comment

With video. Results of the Wellcome Trust funded trial of the experimental anti-Ebola drug TKM-130803 have been published in PLoS Medicine. Using a novel approach designed to get rapid indications of a drug’s effectiveness, the trial showed that at the dose given the drug did not improve survival compared to historic controls.

26th April 2016 • comment

Outbreak: Lessons From Ebola

by ERGO Editorial Team

  Charvy Narain describes how Oxford medics found themselves on the front line

9th February 2016 • comment

Could scientists make history and change the way we deal with outbreaks?

7th January 2016 • comment