Articles - Trial Design

GOST: A generic ordinal sequential trial design for a treatment trial in an emerging pandemic

This paper proposes a generic ordinal sequential trial design (GOST) for a randomised clinical trial comparing an experimental treatment for an emerging infectious disease with standard care. The design is intended as an off-the-shelf, ready-to-use robust and flexible option. This article was first published in PLOS.

Clinical trial for experimental Ebola drug publishes results

With video. Results of the Wellcome Trust funded trial of the experimental anti-Ebola drug TKM-130803 have been published in PLoS Medicine. Using a novel approach designed to get rapid indications of a drug’s effectiveness, the trial showed that at the dose given the drug did not improve survival compared to historic controls.

Outbreak: Lessons From Ebola

  Charvy Narain describes how Oxford medics found themselves on the front line

Ebola: the race to find a cure

Could scientists make history and change the way we deal with outbreaks?