Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Character

by Chloe I Bloom, et. al.,
1st July 2021 • 0 comments

Lassa fever outcomes and prognostic factors in Nigeria (LASCOPE): a prospective cohort study

by Alexandre Duvignaud, et. al.
1st April 2021 • 0 comments

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

by Ryan S Thwaites, et. al.,
10th March 2021 • 0 comments

Potential health and economic impacts of dexamethasone treatment for patients with COVID-19

by Ricardo Águas, et. al.,
10th February 2021 • 0 comments

What are the long-term symptoms and complications of COVID-19: a protocol for a living systematic review

by Melina Michelen, et. al.
14th December 2020 • 0 comments

Hydroxychloroquine for Covid-19: Balancing contrasting claims

by Peter Horby, Jonathan Emberson
1st December 2020 • 0 comments

Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial

by Wang, Y., Zhou, F., Zhang, D. et al.
2nd June 2020 • 0 comments

Global outbreak research: harmony not hegemony

by ISARIC clinical characterisation group
2nd June 2020 • 0 comments

Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: rapid review

by Andrew Dagens, Louise Sigfrid, Erhui Cai, Sam Lipworth, Vincent Cheung, Eli Harris, Peter Bannister, Ishmeala Rigby, Peter Horby
26th May 2020 • 0 comments

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

by ISARIC
22nd May 2020 • 0 comments

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

by Yeming Wang MD, Dingyu Zhang MD, Prof Guanhua Du PhD, Prof Roghui Du MD, Prof Jianping Zhao MD, Prof Yang Jin MD

The Lancet - 29th April 2020 No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models. Read full article

30th April 2020 • 0 comments

Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks.

by Dean NE, Gsell PS, Brookmeyer R, Crawford FW, Donnelly CA, Ellenberg SS, Fleming TR, Halloran ME, Horby P, Jaki T, Krause PR, Longini IM, Mulangu S, Muyembe-Tamfum JJ, Nason MC, Smith PG, Wang R, Henao-Restrepo AM, De Gruttola V
2nd April 2020 • 0 comments

A Trial of Lopinavir-Ritonavir in Adults Hospitalized With Severe Covid-19

by Please see article webpage for full author details
18th March 2020 • 0 comments

Core Minimal Datasets to Advance Clinical Research for Priority Epidemic Diseases.

by Amanda M. Rojek, James Moran, Peter W. Horby
15th February 2020 • 0 comments

Specificity, kinetics and longevity of antibody responses to avian influenza A(H7N9) virus infection in humans.

by Junbo Chen, Huachen Zhu, Peter W. Horby, Qianli Wang, Jiaxin Zhou, Hui Jiang, Liwei Liu, Tianchen Zhang, Yongli Zhang, Xinhua Chen, Xiaowei Deng, Birgit Nikolay, Wei Wang, Simon Cauchemez, Yi Guan, Timothy M. Uyeki, Hongjie Yu
16th January 2020 • 0 comments

Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease: plasma concentrations exceed target levels, with drug accumulation in the most severe patients

by Janet T. Scott, Raman Sharma, Luke W. Meredith, Jake Dunning, Catrin E. Moore, Foday Sahr, Steve Ward, Ian Goodfellow, Peter Horby, RAPIDE-TKM Trial Team
16th January 2020 • 0 comments

Clinical REsearch During Outbreaks (CREDO) Training for Low- and Middle-Income Countries

by Nzelle Delphine Kayem, Amanda Rojek, Emmanuelle Denis, Alex Salam, Andreas Reis, Piero Olliaro, Peter Horby
2nd December 2019 • 0 comments

A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemic

by Alex Salam, Delphine Kayem, Lyndsey Castle and Peter Horby
25th July 2019 • 0 comments

Determinants of Transmission Risk During the Late Stage of the West African Ebola Epidemic

by Conall Watson
18th July 2019 • 0 comments

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

by Louise Sigfrid, Alex Salam and Peter Horby
1st July 2019 • 0 comments