Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trialby Wang, Y., Zhou, F., Zhang, D. et al.
Scope, quality, and inclusivity of clinical guidelines produced early in the covid-19 pandemic: rapid reviewby Andrew Dagens, Louise Sigfrid, Erhui Cai, Sam Lipworth, Vincent Cheung, Eli Harris, Peter Bannister, Ishmeala Rigby, Peter Horby
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Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trialby Yeming Wang MD, Dingyu Zhang MD, Prof Guanhua Du PhD, Prof Roghui Du MD, Prof Jianping Zhao MD, Prof Yang Jin MD
The Lancet - 29th April 2020 No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, and inhibits Middle East respiratory syndrome coronavirus, SARS-CoV-1, and SARS-CoV-2 replication in animal models. Read full article